Methanol → BENZYL 2-HYDROXYMETHYLBENZOATE

HRID 2294544ノート

反応式

HRID 2294544 の反応式
C([C:3]1[CH:18]=[CH:17][C:6]([C:7]([O:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:8])=[CH:5][CH:4]=1)=O.C1C[O:22][CH2:21]C1.CO.[BH4-].[Na+]>O>[OH:22][CH2:21][C:5]1[CH:4]=[CH:3][CH:18]=[CH:17][C:6]=1[C:7]([O:9][CH2:10][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)=[O:8]

参加物

6

反応物 4

HCID 887MethanolHCID 8028TetrahydrofuranHCID 4311764Sodium borohydrideHCID 11528845Benzyl 4-formylbenzoate

生成物 1

HCID 11356918BENZYL 2-HYDROXYMETHYLBENZOATE

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

10.3 g (43 mmol) of benzyl 4-formylbenzoate, 50 ml of THF and 50 ml of methyl alcohol are introduced into a round-bottomed flask. While cooling in an icebath, 820 mg (21.5 mmol) of sodium borohydride are added in small portions and the mixture is stirred at room temperature for two hours. The reaction medium is poured into water, the mixture is extracted with ethyl ether and the organic phase is separated after settling has taken place, dried over magnesium sulphate and evaporated. 10.4 g (100%) of the expected product, melting point 55°-56° C., are collected.

後処理

  1. additionare added in small portions
  2. extractionthe mixture is extracted with ethyl ether
  3. customthe organic phase is separated after settling
  4. dry with materialdried over magnesium sulphate
  5. customevaporated
  6. custom10.4 g (100%) of the expected product, melting point 55°-56° C., are collected

出典と根拠

ORDレコード
ord-4bfe0d89e22d4df6a0d3621b852a97c2
出典データセット
uspto-grants-1997_11
特許番号
US05688817

反応ノート

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