Methanol → 4-(3-tert-Butyl-4-methoxybenzoyloxymethyl)benzenemethanol

HRID 2294582ノート

反応式

HRID 2294582 の反応式
[C:1]([C:5]1[CH:6]=[C:7]([CH:20]=[CH:21][C:22]=1[O:23][CH3:24])[C:8]([O:10][CH2:11][C:12]1[CH:19]=[CH:18][C:15]([CH:16]=[O:17])=[CH:14][CH:13]=1)=[O:9])([CH3:4])([CH3:3])[CH3:2].C1COCC1.CO.[BH4-].[Na+]>O>[C:1]([C:5]1[CH:6]=[C:7]([CH:20]=[CH:21][C:22]=1[O:23][CH3:24])[C:8]([O:10][CH2:11][C:12]1[CH:13]=[CH:14][C:15]([CH2:16][OH:17])=[CH:18][CH:19]=1)=[O:9])([CH3:4])([CH3:2])[CH3:3]

参加物

6

反応物 4

HCID 887MethanolHCID 8028TetrahydrofuranHCID 4311764Sodium borohydrideHCID 214745254-(3-tert-Butyl-4-methoxybenzoyloxymethyl)benzaldehyde

生成物 1

HCID 214745324-(3-tert-Butyl-4-methoxybenzoyloxymethyl)benzenemethanol

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

1.6 g (5 mmol) of the aldehyde obtained in Example 45, 50 ml of THF and 50 ml of methanol are introduced into a round-bottomed flask. 100 mg (2.5 mmol) of sodium borohydride are added in small portions and the mixture is stirred at room temperature for 4 h. The reaction medium is poured into water, the mixture is extracted with ethyl ether and the organic phase is separated after settling has taken place, dried over magnesium sulphate and evaporated.

後処理

  1. extractionthe mixture is extracted with ethyl ether
  2. customthe organic phase is separated after settling
  3. dry with materialdried over magnesium sulphate
  4. customevaporated

出典と根拠

ORDレコード
ord-9042ac85129e49f6a5842e3c018e510b
出典データセット
uspto-grants-1997_11
特許番号
US05688817

反応ノート

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