Sodium Hydroxide → 2-Amino-3-bromo-6-methylpyridine

HRID 2294887ノート

反応式

HRID 2294887 の反応式
[NH2:1][C:2]1[N:7]=[C:6]([CH3:8])[CH:5]=[CH:4][CH:3]=1.[Br:9]Br.[OH-].[Na+]>S(=O)(=O)(O)O.O>[NH2:1][C:2]1[N:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[Br:9]

参加物

6

反応物 3

HCID 14798Sodium HydroxideHCID 157652-Amino-6-methylpyridineHCID 24408Bromine

生成物 1

HCID 27344162-Amino-3-bromo-6-methylpyridine収率 55.2%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 1118Sulfuric Acid溶媒

実験手順

32.4 g (0.3 mole) of 6-aminopicoline was dissolved in a mixture of 28 g of conc. sulfuric acid and 120 ml of water and the resulting solution was cooled in ice water. 52.8 g (0.33 mole) of bromine was added dropwise to the solution over 30 minutes at 0° C. The reaction solution was stirred for 20 minutes at room temperature and neutralized with cold aqueous NaOH solution. The resultant was filtered and the solid was purified with column chromatography using methylene chloride and ethyl acetate as an eluent to obtain 31 g of the title compound (yield 55%).

後処理

  1. filtrationThe resultant was filtered
  2. customthe solid was purified with column chromatography

出典と根拠

ORDレコード
ord-3937fc1e153a4492b650464d69a4578b
出典データセット
uspto-grants-1997_11
特許番号
US05691348

反応ノート

読み込み中…