Lithium Hydroxide → Lithium 2-methyl-2-(5-pyrimidinyl)propionate
反応式
[CH3:1][C:2]([C:9]1[CH:10]=[N:11][CH:12]=[N:13][CH:14]=1)([CH3:8])[C:3]([O:5]CC)=[O:4].[OH-].[Li+:16].C1COCC1>C(O)(=O)C>[CH3:8][C:2]([C:9]1[CH:14]=[N:13][CH:12]=[N:11][CH:10]=1)([CH3:1])[C:3]([O-:5])=[O:4].[Li+:16]参加物
5
実験手順
A mixture of ethyl 2-methyl-2-(5-pyrimidinyl)propionate (4.64 g), 1.0N lithium hydroxide (26 mL) and THF (100 mL) was heated to reflux under argon for 26 h. The mixture was allowed to cool, adjusted to pH 7 with acetic acid, and concentrated to dryness to give 4.11 g of lithium 2-methyl-2-(5-pyrimidinyl)propionate as a pale solid.
後処理
- temperaturewas heated
- temperatureto reflux under argon for 26 h
- temperatureto cool
- concentrationconcentrated to dryness
出典と根拠
- ORDレコード
- ord-f05915991b0345408594eb1106f8a1bf
- 出典データセット
- uspto-grants-1997_11
- 特許番号
- US05691323
反応ノート
読み込み中…