L-Leucine → HCID 13316869、化合物

HRID 2295514ノート

反応式

HRID 2295514 の反応式
[C:1]([S:4][CH2:5][CH2:6][C:7]([N:9]1[C@H:13]([C:14]([OH:16])=O)[CH2:12][S:11][C@@H:10]1[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[OH:23])=[O:8])(=[O:3])[CH3:2].CN1CCOCC1.C(Cl)(=O)OCC(C)C.[NH2:39][C@H:40]([C:45]([OH:47])=[O:46])[CH2:41][CH:42]([CH3:44])[CH3:43]>C1COCC1.C(N(CC)CC)C>[C:1]([S:4][CH2:5][CH2:6][C:7]([N:9]1[C@H:13]([C:14]([NH:39][C@H:40]([C:45]([OH:47])=[O:46])[CH2:41][CH:42]([CH3:44])[CH3:43])=[O:16])[CH2:12][S:11][C@@H:10]1[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[OH:23])=[O:8])(=[O:3])[CH3:2]

参加物

7

反応物 4

HCID 6106L-LeucineHCID 79724-MethylmorpholineHCID 62365Isobutyl chloroformateHCID 13316857HCID 13316857、化合物

生成物 1

HCID 13316869HCID 13316869、化合物収率 77%

試薬・触媒・溶媒 2

HCID 8028Tetrahydrofuran溶媒HCID 8471Triethylamine溶媒

実験手順

The suspension of mixed anhydride in THF is prepared by using 1.78 g of (2R,4R)-3-(S-acetyl-3-mercaptopropanoyl)-2-(2-hydroxyphenyl)-4-thiazolidinecarboxylic acid, 0.51 g of N-methylmorpholine and 0.68 g of isobutyl chlorocarbonate. To the suspension the aqueous solution of 1.31 g of L-leucine and 1.0 g of triethylamine is added, and treated in the same manner as Example 1 to give 1.8 g (77%) of the titled compound.

後処理

  1. customis prepared
  2. additiontreated in the same manner as Example 1

出典と根拠

ORDレコード
ord-356b968756d84661b6dfa31ec3763f21
出典データセット
uspto-grants-1984_01
特許番号
US04425333

反応ノート

読み込み中…