Sulfuric Acid → 2-hydroxyimino-N-phenylacetamide

HRID 2298014

反応式

HRID 2298014 の反応式
[C:1]([NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)(=[O:6])[CH2:2]C(C)=O.[N:14]([O-])=[O:15].[Na+].S(=O)(=O)(O)O>[OH-].[Na+]>[OH:15][N:14]=[CH:2][C:1]([NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:6]

参加物

5

反応物 3

HCID 1118Sulfuric AcidHCID 7592AcetoacetanilideHCID 23668193Sodium Nitrite

生成物 1

HCID 63990632-hydroxyimino-N-phenylacetamide収率 98.5%

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

反応条件

温度
0 °C

実験手順

Acetoacetanilide (25.0 g, 0.14 mol) and sodium nitrite (12.65 g, 0.18 mol) were dissolved in aqueous sodium hydroxide solution (140 ml, 1 N) and the resulting solution was added dropwise over 20 min to an aqueous solution of sulfuric acid (120 ml conc. H2SO4 in 950 ml water) cooled in an ice bath. The reaction mixture was stirred at 0° C. for 30 min, then the precipitate was filtered and washed with water to yield 2-hydroxyiminoacetanilide (22.64 g, 78% yield) as a pale yellow solid.

後処理

  1. temperaturecooled in an ice bath
  2. filtrationthe precipitate was filtered
  3. washwashed with water

出典と根拠

ORDレコード
ord-c916ce4de7414023bfc41ad8ba0d765e
出典データセット
uspto-grants-2002_12
特許番号
US06492401B1

関連ノート

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