Lithium Hydroxide → HCID 12044408、化合物
反応式
[CH3:1][N:2]([CH3:20])[C:3]([C:5]1[C:6]([C:16]([O:18]C)=[O:17])=[N:7][N:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[N:9]=1)=[O:4].[Li+].[OH-]>C1COCC1>[CH3:1][N:2]([CH3:20])[C:3]([C:5]1[C:6]([C:16]([OH:18])=[O:17])=[N:7][N:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[N:9]=1)=[O:4]参加物
4
反応条件
- 温度
- 23 °C
実験手順
A solution of methyl 5-(N,N-dimethylcarbamoyl)-2-phenyl-2H-1,2,3-triazole-4-carboxylate (0.195 g, 0.71 mmol) in THF (3.6 mL) at 23° C. was treated with LiOH (1 M aq., 3.6 mL, 3.6 mmol). The resulting suspension was stirred for 15 min at 23° C. and partitioned between ether and water. The aqueous layer was acidified to pH 1 with HCl (conc.). The resulting white solid was collected by filtration, washed with water, and air-dried to provide 0.164 g (89%) of 5-(N,N-dimethylcarbamoyl)-2-phenyl-2H-1,2,3-triazole-4-carboxylic acid.