Ethylene glycol dimethacrylate → Estradiol Benzoate

HRID 23004

反応式

HRID 23004 の反応式
[CH2:1]=[CH:2][C:3]1C=CC=CC=1.CC(C(O[CH2:15][CH2:16][O:17][C:18]([C:20]([CH3:22])=[CH2:21])=[O:19])=O)=C.[CH3:23][CH2:24]C(N=NC(C#N)(CC)C)(C#N)C.[CH:37]1(O)CCCC[CH2:38]1.[CH2:44]([OH:56])[CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][CH2:54][CH3:55]>O>[CH3:37][C@@:38]12[C@@H:44]([OH:56])[CH2:45][CH2:46][C@H:47]1[C@H:48]1[C@@H:53]([C:52]3[CH:23]=[CH:24][C:16]([O:17][C:18]([C:20]4[CH:21]=[CH:1][CH:2]=[CH:3][CH:22]=4)=[O:19])=[CH:15][C:51]=3[CH2:50][CH2:49]1)[CH2:54][CH2:55]2

参加物

7

反応物 5

HCID 7355Ethylene glycol dimethacrylateHCID 7501StyreneHCID 7966CyclohexanolHCID 81931-DodecanolHCID 930792,2'-Azobis(2-methylbutyronitrile)

生成物 1

HCID 222757Estradiol Benzoate

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

反応条件

温度
90 °C

実験手順

To a 500 mL glass resin keftle (equipped with water-driven condenser, air-driven agitator with Teflon® paddle, N2 sweep, and heating mantle) 100 mL water with 1.2 g polyvinylpyrolidone was charged. This suspending medium was heated to approximately 90° C. and agitation of 700 rpm was then achieved. A pre-heated glass syringe was used to dropwise add a previously mixed reaction mixture of 0.82 g MAA, 0.99 g styrene, 18.2 g EGDMA, 1.78 g EB, 0.16 g VAZO-67®, 18.71 g cyclohexanol, and 1.96 g dodecylalcohol to the water by gravity feed. Dropwise addition of the monomer-template reaction mixture was complete in 35 min. Polymerization was complete 20 min thereafter, and the polymer beads were recovered via Buchner filtration.

後処理

  1. customA pre-heated glass syringe was used
  2. additionto dropwise add
  3. additionDropwise addition of the monomer-template reaction mixture
  4. customPolymerization
  5. waitwas complete 20 min
  6. filtrationthe polymer beads were recovered via Buchner filtration

出典と根拠

ORDレコード
ord-cd593ef36b234da0a3c9dcdbaf4a3517
出典データセット
uspto-grants-2005_02
特許番号
US06849701B2

関連ノート

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