Hydrogen Bromide → 4,5,6,7-Tetrahydrothieno(3,2-c)pyridine

HRID 2301108ノート

反応式

HRID 2301108 の反応式
Cl.[S:2]1[C:10]2[CH2:9][CH2:8][NH:7][CH2:6][C:5]=2[CH:4]=[C:3]1C(O)=O.Br.[OH-].[Na+]>>[S:2]1[C:10]2[CH2:9][CH2:8][NH:7][CH2:6][C:5]=2[CH:4]=[CH:3]1

参加物

4

反応物 3

HCID 260Hydrogen BromideHCID 14798Sodium HydroxideHCID 686439894,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid hydrochloride

生成物 1

HCID 30850764,5,6,7-Tetrahydrothieno(3,2-c)pyridine

実験手順

4,5,6,7-Tetrahydro-thieno[3,2-c]pyridine-2-carboxylic acid hydrochloride (260 mg, 1.2 mmol) was mixed with 47% hydrogen bromide aqueous solution (3 ml) and heated under reflux for 4 hours. The reaction solution was returned to room temperature and alkalified by adding sodium hydroxide aqueous solution (5 N), and the reaction product was extracted with diethyl ether, washed with saturated brine and then dried with anhydrous magnesium sulfate. By evaporating the solvent from the organic layer under a reduced pressure, 160 mg (1.1 mmol, 95% in yield) of the title compound was obtained.

後処理

  1. temperatureheated
  2. temperatureunder reflux for 4 hours
  3. customwas returned to room temperature
  4. extractionthe reaction product was extracted with diethyl ether
  5. washwashed with saturated brine
  6. dry with materialdried with anhydrous magnesium sulfate
  7. customBy evaporating the solvent from the organic layer

出典と根拠

ORDレコード
ord-ef3905e6c0ad4871b5362ba542da70ed
出典データセット
uspto-grants-2002_12
特許番号
US06498251B1

反応ノート

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