4-Ethoxybenzaldehyde → alpha-(4-Ethoxyphenyl)-N-tert-octylnitrone

HRID 2303554

反応式

HRID 2303554 の反応式
C(OC1C=CC([NH:10][C:11]([CH2:14][C:15]([CH3:18])([CH3:17])[CH3:16])([CH3:13])[CH3:12])=CC=1)C.ClC1C=C(C=CC=1)C(OO)=[O:24].[BH4-].[Na+].[CH2:32]([O:34][C:35]1[CH:42]=[CH:41][C:38]([CH:39]=O)=[CH:37][CH:36]=1)[CH3:33].C(N)(CC(C)(C)C)(C)C>C(Cl)Cl.CO>[CH2:32]([O:34][C:35]1[CH:42]=[CH:41][C:38]([CH:39]=[N+:10]([C:11]([CH2:14][C:15]([CH3:18])([CH3:17])[CH3:16])([CH3:13])[CH3:12])[O-:24])=[CH:37][CH:36]=1)[CH3:33]

参加物

8

反応物 5

HCID 248344-EthoxybenzaldehydeHCID 61017tert-OctylamineHCID 70297m-Chloroperbenzoic acidHCID 4311764Sodium borohydrideHCID 18433750HCID 18433750、化合物

生成物 1

HCID 86587909alpha-(4-Ethoxyphenyl)-N-tert-octylnitrone

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 6344Dichloromethane溶媒

実験手順

The title compound was prepared by oxidation of N-(4-ethoxyphenyl)-N-tert-octylamine with m-chloroperoxybenzoic acid in methylene chloride. The amine was synthesized via NaBH4 reduction from the corresponding imine which was acquired by condensation of 4-ethoxybenzaldehyde and tert-octylamine in methanol. The title compound was isolated in 65.0% overall yield as white crystals, m.p. 100.8° C. (Rf=0.33 on silica gel plate using hexanes:EtOAc, 7:3, v/v, as an eluant).

出典と根拠

ORDレコード
ord-f1164838ac174021840e26925f9ad108
出典データセット
uspto-grants-2002_08
特許番号
US06433008B1

関連ノート

読み込み中…