Triethylamine → N-[(4-bromophenyl)methyl]-1-pyrrolidinecarboxamide

HRID 230635

反応式

HRID 230635 の反応式
[Br:1][C:2]1[CH:11]=[CH:10][C:5]([CH2:6][N:7]=[C:8]=[O:9])=[CH:4][CH:3]=1.[CH2:12]([N:14](CC)[CH2:15][CH3:16])[CH3:13].N1CCCC1>C(#N)C>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][NH:7][C:8]([N:14]2[CH2:15][CH2:16][CH2:13][CH2:12]2)=[O:9])=[CH:10][CH:11]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 31268PyrrolidineHCID 43746174-Bromobenzyl isocyanate

生成物 1

HCID 57762826N-[(4-bromophenyl)methyl]-1-pyrrolidinecarboxamide収率 99.7%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A solution of 4-bromobenzylisocyanate (408 mg, 1.92 mmol) in acetonitrile (15 ml) was treated with triethylamine (390 mg, 3.86 mmol) followed by pyrrolidine (137 mg, 1.93 mmol) at room temperature with stirring under argon. The reaction was stirred at 20° C. for 30 minutes and then partitioned between ethyl acetate (10 ml) and water (20 ml). The organic layer was dried over sodium sulphate and evaporated under reduced pressure to give the title compound as a colourless solid (542 mg, 99%).

後処理

  1. stirringThe reaction was stirred at 20° C. for 30 minutes
  2. custompartitioned between ethyl acetate (10 ml) and water (20 ml)
  3. dry with materialThe organic layer was dried over sodium sulphate
  4. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-f443a1ad5c914714b68e4eed5bc82f15
出典データセット
uspto-grants-2009_07
特許番号
US07566735B2

関連ノート

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