Ethanol → HCID 136347709、化合物

HRID 2306660ノート

反応式

HRID 2306660 の反応式
[C:1]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][C:5]=1[OH:14])(=O)[CH3:2].CCO.Cl.[NH2:19][OH:20]>[OH-].[Na+]>[OH:14][C:5]1[CH:6]=[C:7]([CH:12]=[CH:13][C:4]=1[C:1](=[N:19][OH:20])[CH3:2])[C:8]([O:10][CH3:11])=[O:9]

参加物

5

反応物 3

HCID 702EthanolHCID 443297Hydroxyamine hydrochlorideHCID 22610067Methyl 4-acetyl-3-hydroxybenzoate

生成物 1

HCID 136347709HCID 136347709、化合物収率 78.1%

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

実験手順

Methyl 4-acetyl-3-hydroxybenzoate (350 mg, 1.8 mmole) is combined with 5 ml absolute EtOH. The solution is treated with hydroxylamine hydrochloride (125 mg, 1.8 mmole) dissolved in 0.9 ml 2N aqueous NaOH, and the reaction is stirred overnight at rt. The volatiles are removed in vacuo and the residue is washed with H2O, collected, and dried to give 294 mg (78%) of methyl 3-hydroxy-4-[N-hydroxyethanimidoyl]benzoate as a tan solid. MS (EI) m/z: 209 (M+).

後処理

  1. customThe volatiles are removed in vacuo
  2. washthe residue is washed with H2O
  3. customcollected
  4. customdried

出典と根拠

ORDレコード
ord-21289b0afe6342acbdf4645abada056c
出典データセット
uspto-grants-2004_12
特許番号
US06828330B2

反応ノート

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