Lithium Hydroxide → 2-Methoxy-4-(3-methyl-pyrazol-1-yl)-benzoic Acid
反応式
[CH3:1][O:2][C:3]1[CH:12]=[C:11]([N:13]2[CH:17]=[CH:16][C:15]([CH3:18])=[N:14]2)[CH:10]=[CH:9][C:4]=1[C:5]([O:7]C)=[O:6].[OH-].[Li+]>O1CCCC1>[CH3:1][O:2][C:3]1[CH:12]=[C:11]([N:13]2[CH:17]=[CH:16][C:15]([CH3:18])=[N:14]2)[CH:10]=[CH:9][C:4]=1[C:5]([OH:7])=[O:6]参加物
4
実験手順
A solution of 2-methoxy-4-(3-methyl-pyrazol-1-yl)-benzoic acid methyl ester (0.5 g) from Example 105 in tetrahydrofuran (2.5 ml) was treated with 1 N lithium hydroxide (2.13 ml) at room temperature. After 14 hours the solvent was removed in vacuo and the title compound precipitated by the addition at 0° C. of 1N hydrochloric acid. After drying under vacuum 0.42 g of the title compound was obtained as a solid. MS, m/z: 232 (M)+.
後処理
- customAfter 14 hours the solvent was removed in vacuo
- customthe title compound precipitated by the addition at 0° C. of 1N hydrochloric acid
- dry with materialAfter drying under vacuum 0.42 g of the title compound
- customwas obtained as a solid
出典と根拠
- ORDレコード
- ord-b61e8174633441fdb29fd1287af06410
- 出典データセット
- uspto-grants-2004_12
- 特許番号
- US06831079B1
反応ノート
読み込み中…