1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 10146981、化合物

The product from Example 36B (114 mg, 0.2 mmol), 4-methoxybenzenesulfonamide (37 mg, 0.2 mmol), DMAP (25 mg, 0.2 mmol), and EDCI (78 mg, 0.4 mmol) were combined in THF (10 mL) at room temperature. After stirring overnight, the mixture was concentrated under reduced pressure and CH2Cl2 (20 mL) was added. The mixture was washed with water and the organic layer concentrated under reduced pressure. The residue was purified via HPLC to provide the title compounds. 1H (500 MHz; DMSO-d6) δ6.4-8.6 (m, br., 20H) 5.0 (m, 1H) 4.7 (m, 1H) 4.1 (m, 1H) 3.5 (br, 3H) 1.4-2.7 (m, 6H); MS (M+H)+735.

1. concentrationthe mixture was concentrated under reduced pressure and CH2Cl2 (20 mL)
2. additionwas added
3. washThe mixture was washed with water
4. concentrationthe organic layer concentrated under reduced pressure
5. customThe residue was purified via HPLC

ORDレコード

ord-8fee3853e22243448830cb8e3dedd1b6

出典データセット

uspto-grants-2004_12

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US06831193B2