2'-Hydroxyacetophenone → Cyclododec-2-en-1-ol
反応式
[OH-].[Ca+2].[OH-].O[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11](=[O:13])[CH3:12]>>[CH:11]1([OH:13])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:5][CH2:7][CH2:6][CH2:5][CH:10]=[CH:12]1参加物
3
反応条件
- 温度
- 215 °C
実験手順
A mixture of 180 parts of trans-1,2-epoxidodecane, 6 parts of calcium hydroxide and 0.3 parts of o-hydroxyacetophenone was refluxed at 210-220° C. for 3 hours in a three-necked flask equipped agitator, Dean-Stark trap, and temperature probe. After cooling and filtration 175 parts of the mixture containing 15% starting epoxide and 74% cyclododec-2-en-1-ol (85% conversion, 87% selectivity) was obtained.
後処理
- customequipped agitator, Dean-Stark trap, and temperature probe
- temperatureAfter cooling
- filtrationfiltration 175 parts of the mixture
- additioncontaining 15%
出典と根拠
- ORDレコード
- ord-91497092c4104addbea1feeab9a36f7a
- 出典データセット
- uspto-grants-2004_12
- 特許番号
- US06835686B2
反応ノート
読み込み中…