Hydrochloric Acid → 2-Carboxy-4-methoxy-3-(2-phenylethyl)benzo[b]thiophene

HRID 230883ノート

反応式

HRID 230883 の反応式
[CH3:1][O:2][C:3]1[C:11]2[C:10]([CH2:12][CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[C:9]([C:20]([O:22]C)=[O:21])[S:8][C:7]=2[CH:6]=[CH:5][CH:4]=1.CO.[OH-].[Na+].Cl>O1CCCC1>[C:20]([C:9]1[S:8][C:7]2[CH:6]=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[C:11]=2[C:10]=1[CH2:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([OH:22])=[O:21]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 231035484-Methoxy-2-methoxycarbonyl-3-(2-phenylethyl)benzo[b]thiophene

生成物 1

HCID 231035202-Carboxy-4-methoxy-3-(2-phenylethyl)benzo[b]thiophene収率 95.9%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 4-methoxy-2-methoxycarbonyl-3-(2-phenylethyl)benzo[b]thiophene (1.09 g) in tetrahydrofuran (6 mL)-methanol (21 mL) was added 1 mol/L aqueous sodium hydroxide solution (21 mL), and the mixture was heated for reflux for 3.5 hours. The reaction mixture was cooled to room temperature. To the mixture was added 2 mol/L hydrochloric acid (11 mL), and the precipitated crystals were collected by filtration. The crystals were dried under reduced pressure to give the title compound (1 g).

後処理

  1. temperaturethe mixture was heated
  2. temperaturefor reflux for 3.5 hours
  3. filtrationthe precipitated crystals were collected by filtration
  4. customThe crystals were dried under reduced pressure

出典と根拠

ORDレコード
ord-577da371a756430ebeb9460efc8effec
出典データセット
uspto-grants-2009_07
特許番号
US07566699B2

反応ノート

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