Glycerol → 3-Trityloxypropane-1,2-diol

HRID 2309296

反応式

HRID 2309296 の反応式
[OH:1][CH2:2][CH:3]([CH2:5][OH:6])[OH:4].[C:7](Cl)([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>N1C=CC=CC=1>[C:7]([O:1][CH2:2][CH:3]([OH:4])[CH2:5][OH:6])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)([C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

参加物

4

反応物 2

HCID 753GlycerolHCID 6456Trityl chloride

生成物 1

HCID 28828273-Trityloxypropane-1,2-diol

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

100 mmol of the glycerol derivative obtained in (b) in 10 ml of pyridine were reacted at room temperature overnight with 101 mmol of trityl chloride. The pyridine was removed under reduced pressure and the residue was taken up in 100 ml of ether. The solution was filtered, the ether was removed and the residue was treated with 10 ml of pyridine, 1 ml of water and 1 g of potassium bicarbonate and stirred at room temperature for 1 hour. The solvent was removed under reduced pressure and moisture residues were removed with toluene. The residue was taken up in toluene and chromatographed on silica gel with ether/pyridine (99:1). There was obtained (RS)-1-O-[3RS,7R,11R)-3,7,11,15-tetramethylhexadecyl]-3-O-tritylglycerol as an oil.

後処理

  1. customThe pyridine was removed under reduced pressure
  2. filtrationThe solution was filtered
  3. customthe ether was removed
  4. additionthe residue was treated with 10 ml of pyridine, 1 ml of water and 1 g of potassium bicarbonate
  5. customThe solvent was removed under reduced pressure and moisture residues
  6. customwere removed with toluene
  7. customchromatographed on silica gel with ether/pyridine (99:1)

出典と根拠

ORDレコード
ord-82a5eb09337b4f7cbbae81b5fc6c9baa
出典データセット
uspto-grants-1987_09
特許番号
US04694084

関連ノート

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