4,4'-Dichlorobenzhydryl chloride → 1-[bis(4-chlorophenyl)methyl]-1H-1,2,3-triazole

HRID 231214

反応式

HRID 231214 の反応式
[NH:1]1[CH:5]=[CH:4][N:3]=[N:2]1.[H-].[Na+].[Cl:8][C:9]1[CH:23]=[CH:22][C:12]([CH:13](Cl)[C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)=[CH:11][CH:10]=1>CN(C)C=O>[Cl:8][C:9]1[CH:10]=[CH:11][C:12]([CH:13]([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)[N:2]2[N:3]=[CH:4][CH:5]=[N:1]2)=[CH:22][CH:23]=1.[Cl:8][C:9]1[CH:10]=[CH:11][C:12]([CH:13]([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)[N:1]2[CH:5]=[CH:4][N:3]=[N:2]2)=[CH:22][CH:23]=1

参加物

6

反応物 3

HCID 130784,4'-Dichlorobenzhydryl chlorideHCID 24758Sodium hydrideHCID 178418936HCID 178418936、化合物

生成物 2

HCID 143906541-[bis(4-chlorophenyl)methyl]-1H-1,2,3-triazoleHCID 200349022-[bis(4-chlorophenyl)methyl]-2H-1,2,3-triazole

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
25 °C

実験手順

Following the general procedure of Example 1B, 5.0 g of 1,2,3-triazole in 100 ml fo dimethylformamide were treated first with 1.44 g of sodium hydride (60% in mineral oil), and then with 5.0 g of 4.4'-dichlorobenzhydryl chloride. The reactants were stirred overnight at about 25° C. and then heated for 1 hour on a steam bath. Chromatography of the residue after work-up provided 2.4 g of the undesired 2-[bis(4-chlorophenyl)methyl]-2H-1,2,3-triazole and 3.1 g of the desired title product, m.p. 124°-125° C.

後処理

  1. temperatureheated for 1 hour on a steam bath

出典と根拠

ORDレコード
ord-809019cea303426b8bafa091cd2074d2
出典データセット
uspto-grants-1989_07
特許番号
US04845227

関連ノート

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