Hydrochloric Acid → 2-Acetyl-4-methoxycyclohexanone

HRID 231219

反応式

HRID 231219 の反応式
[C:1](OCC)(=[O:3])[CH3:2].[H-].[Na+].[CH3:9][O:10][CH:11]1[CH2:16][CH2:15][C:14](=[O:17])[CH2:13][CH2:12]1.Cl>C1C=CC=CC=1.O.CO>[C:1]([CH:15]1[CH2:16][CH:11]([O:10][CH3:9])[CH2:12][CH2:13][C:14]1=[O:17])(=[O:3])[CH3:2]

参加物

8

反応物 4

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 24758Sodium hydride2 回HCID 5350284-Methoxycyclohexanone

生成物 1

HCID 136327242-Acetyl-4-methoxycyclohexanone収率 43.2%

試薬・触媒・溶媒 3

HCID 241Benzene溶媒HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

To 2.5 g of ethyl acetate was added 1.12 g of 60% sodium hydride and, a solution of 1.78 g of 4-methoxycyclohexanone in benzene was added to the mixture. After reacting at 40° C. for 3 hours, methanol was added to decompose an excess of sodium hydride, which was poured into water. The mixture was neutralized with hydrochloric acid ahd extracted with ether to give 1.02 g of 2-acetyl-4-methoxycyclohexanone.

後処理

  1. extractionahd extracted with ether

出典と根拠

ORDレコード
ord-be6ece670b8f49489d05b7e0c43e9ab9
出典データセット
uspto-grants-1989_07
特許番号
US04845228

関連ノート

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