Epichlorohydrin → 1,2-Epoxy-3-(12-cyclohexyldodecyloxy)propane

HRID 231267

反応式

HRID 231267 の反応式
[CH:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][OH:19])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:20]([CH:22]1[O:24][CH2:23]1)Cl.[OH-].[Na+]>[Cl-].C([N+](C)(C)C)CCCCCCCCCCCCCCC.C1(C)C=CC=CC=1>[O:24]1[CH:22]([CH2:20][O:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)[CH2:23]1

参加物

6

反応物 3

HCID 7835EpichlorohydrinHCID 14798Sodium HydroxideHCID 1487778512-Cyclohexyldodecanol

生成物 1

HCID 148777861,2-Epoxy-3-(12-cyclohexyldodecyloxy)propane収率 71.2%

試薬・触媒・溶媒 2

HCID 8154Hexadecyltrimethylammonium chloride触媒HCID 1140Toluene溶媒

反応条件

温度
60 °C

実験手順

A mixture containing 26.5 g of 12-cyclohexyldodecanol, 27.4 g of epichlorohydrin, 52.6 g of a 50% aqueous sodium hydroxide solution, 2.0 g of cetyltrimethylammonium chloride and 300 ml of toluene is stirred at 60° C. for 24 hours. The resulting reaction mixture is then washed with water, dried and concentrated to leave a residue which in turn is purified by silica gel chromatography to obtain 22.8 g of the captioned compound as a colorless oily substance.

後処理

  1. customThe resulting reaction mixture
  2. washis then washed with water
  3. customdried
  4. concentrationconcentrated
  5. customto leave a residue which in turn
  6. customis purified by silica gel chromatography

出典と根拠

ORDレコード
ord-8d23ce74afe44c119a199939851f91c9
出典データセット
uspto-grants-1989_07
特許番号
US04845219

関連ノート

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