Hydrochloric Acid → Diethyl 2-(5-nitropyridin-2-yl)malonate

HRID 231633ノート

反応式

HRID 231633 の反応式
[OH-].[Na+].[C:3]([O:11][CH2:12][CH3:13])(=[O:10])[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6].Cl[C:15]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][N:16]=1.Cl>CN(C)C=O.O>[N+:21]([C:18]1[CH:19]=[CH:20][C:15]([CH:4]([C:5]([O:7][CH2:8][CH3:9])=[O:6])[C:3]([O:11][CH2:12][CH3:13])=[O:10])=[N:16][CH:17]=1)([O-:23])=[O:22]

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 7761Diethyl MalonateHCID 14798Sodium HydroxideHCID 783082-Chloro-5-nitropyridine

生成物 1

HCID 2794558Diethyl 2-(5-nitropyridin-2-yl)malonate

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒2 回

実験手順

2.7 g (67.5 mmol) of powdered NaOH are introduced into 10.8 g (675 mmol) of diethyl malonate in 30 ml of dimethylformamide at room temperature, with cooling, a solution of 5 g (31 mmol) of 2-chloro-5-nitropyridine in dimethylformamide is then added dropwise and the mixture is stirred at room temperature until the reaction is complete. For working up, the mixture is poured onto 500 ml of water and acidified with concentrated HCl and the precipitate is filtered off with suction and rinsed with petroleum ether.

後処理

  1. temperaturewith cooling
  2. filtrationthe precipitate is filtered off with suction
  3. washrinsed with petroleum ether

出典と根拠

ORDレコード
ord-fa369518d4ad4be091cbebb3c232b350
出典データセット
uspto-grants-1989_07
特許番号
US04847382

反応ノート

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