3-Thiophenecarboxylic acid, tetrahydro-4-oxo-, methyl ester → Methyl 4-aminothiophene-3-carboxylate Hydrochloride

HRID 231641

反応式

HRID 231641 の反応式
O=[C:2]1[CH2:6][S:5][CH2:4][CH:3]1[C:7]([O:9][CH3:10])=[O:8].[ClH:11].[NH2:12]O>C(#N)C>[ClH:11].[NH2:12][C:2]1[C:3]([C:7]([O:9][CH3:10])=[O:8])=[CH:4][S:5][CH:6]=1

参加物

4

反応物 2

HCID 984243-Thiophenecarboxylic acid, tetrahydro-4-oxo-, methyl esterHCID 443297Hydroxyamine hydrochloride

生成物 1

HCID 2777609Methyl 4-aminothiophene-3-carboxylate Hydrochloride収率 77.4%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

4-Oxo-3-methoxycarbonyltetrahydrothiophene (3.9 g) was heated under reflux for 1 hour with hydroxylamine hydrochloride (2 g) in acetonitrile 10 ml). The mixture was then cooled and the solid portion was filtered off and washed with dry diethyl ether to afford the title compound (3.65 g), m.p. 203°-204° C.

後処理

  1. temperatureThe mixture was then cooled
  2. filtrationthe solid portion was filtered off
  3. washwashed with dry diethyl ether

出典と根拠

ORDレコード
ord-ee69670acd5843ca96cce8c411cf44b0
出典データセット
uspto-grants-1989_07
特許番号
US04847386

関連ノート

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