2,3-Dihydroxybutanedioic Acid → HCID 178424608、化合物

HRID 232022ノート

反応式

HRID 232022 の反応式
[N:1]1([CH2:7][C:8]2[CH:9]=[N:10][N:11]([O:13][CH2:14][CH2:15][CH2:16][NH2:17])[CH:12]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.CS[C:20]1[NH:21][CH:22]=[C:23]([CH2:27][C:28]2[CH:29]=[CH:30][C:31]([CH3:34])=[N:32][CH:33]=2)[C:24](=[O:26])[N:25]=1.C(O)(=O)C(C(C(O)=O)O)O>N1C=CC=CC=1.C(O)(C)C>[N:1]1([CH2:7][C:8]2[CH:9]=[N:10][N:11]([O:13][CH2:14][CH2:15][CH2:16][NH:17][C:20]3[NH:21][CH:22]=[C:23]([CH2:27][C:28]4[CH:29]=[CH:30][C:31]([CH3:34])=[N:32][CH:33]=4)[C:24](=[O:26])[N:25]=3)[CH:12]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

6

反応物 3

HCID 8752,3-Dihydroxybutanedioic AcidHCID 138232143-(4-Piperidinomethylpyrazol-1-yloxy)propylamineHCID 178503537HCID 178503537、化合物

生成物 1

HCID 178424608HCID 178424608、化合物

試薬・触媒・溶媒 2

HCID 1049Pyridine溶媒HCID 3776Isopropanol溶媒

実験手順

3.5 g of 3-(4-piperidinomethylpyrazol-1-yloxy)propylamine and 3.6 g of 2-methylthio-5-(2-methylpyrid-5-ylmethyl)-1H-pyrimid-4-one in 30 ml of pyridine are refluxed for 30 hours. The pyridine is distilled off and the residue is then chromatographed over neutral Al2O3 (activity level III) using methylene chloride/3% strength methanol as the mobile phase. The oil obtained is reacted with tartaric acid in isopropanol to give an amorphous solid.

後処理

  1. distillationThe pyridine is distilled off
  2. customthe residue is then chromatographed over neutral Al2O3 (activity level III)
  3. customThe oil obtained
  4. customto give an amorphous solid

出典と根拠

ORDレコード
ord-e8522393088a431c8f6a3da6b41f6ee4
出典データセット
uspto-grants-1989_07
特許番号
US04851410

反応ノート

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