Tetrahydrofuran → HCID 20031369、化合物

HRID 232258ノート

反応式

HRID 232258 の反応式
O1CCCC1.[CH2:6]([N:11]1[CH2:16][CH2:15][N:14]([C:17]([CH:19]2[CH2:21][CH:20]2[C:22](O)=[O:23])=O)[CH2:13][CH2:12]1)[CH2:7][CH2:8][CH2:9][CH3:10].[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH-].[Na+]>O>[CH2:6]([N:11]1[CH2:12][CH2:13][N:14]([CH2:17][CH:19]2[CH2:21][CH:20]2[CH2:22][OH:23])[CH2:15][CH2:16]1)[CH2:7][CH2:8][CH2:9][CH3:10]

参加物

6

反応物 4

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 20031396HCID 20031396、化合物HCID 21226445Aluminium lithium hydride

生成物 1

HCID 20031369HCID 20031369、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

To 100 mL of tetrahydrofuran is added 24.0 g (0.1 mol) of 2-[(4-pentylpiperazin-1-yl)carbonyl]cyclopropanecarboxylic acid and 13.6 g (0.4 mol) of lithium aluminum hydride. Reflux the reaction and monitor by thin-layer chromatography. Upon completion add 14 mL of H2O, 14 mL of 15% aqueous NaOH, and 42 mL of H2O. Remove the precipitate by suction filtration through celite and remove the solvent in vacuo to obtain the title compound.

後処理

  1. temperatureReflux
  2. customthe reaction and monitor by thin-layer chromatography
  3. customRemove the precipitate
  4. filtrationby suction filtration through celite
  5. customremove the solvent in vacuo

出典と根拠

ORDレコード
ord-de1f78178e17401c8a8424ca6e05eeea
出典データセット
uspto-grants-1989_07
特許番号
US04851526

反応ノート

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