Butyl iodide → HCID 20031349、化合物

HRID 232302ノート

反応式

HRID 232302 の反応式
[NH:1]1[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]([C:8]#[N:9])[CH2:2]1.I[CH2:11][CH2:12][CH2:13][CH3:14]>C(#N)C>[CH2:11]([N:1]1[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]([C:8]#[N:9])[CH2:2]1)[CH2:12][CH2:13][CH3:14]

参加物

4

反応物 2

HCID 10962Butyl iodideHCID 13498182HCID 13498182、化合物

生成物 1

HCID 20031349HCID 20031349、化合物

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To 50 mL of acetonitrile is added 1 g (8.0 mmol) of hexahydro-1H-azepine-3-carbonitrile and 2.7 g (15 mmol) of iodobutane. Heat the reaction under reflux and monitor the reaction by thin-layer chromatography. Upon completion remove the solvent in vacuo and add 50 mL sat. sodium bicarbonate and 50 mL methylene chloride. Separate the organic layer and dry over Na2SO4. Filter off the drying agent and remove the solvent in vacuo to obtain the title compound.

後処理

  1. temperatureHeat
  2. customthe reaction
  3. temperatureunder reflux
  4. customthe reaction by thin-layer chromatography
  5. customUpon completion remove the solvent in vacuo
  6. additionadd 50 mL sat. sodium bicarbonate and 50 mL methylene chloride
  7. customSeparate the organic layer
  8. dry with materialdry over Na2SO4
  9. filtrationFilter off the drying agent
  10. customremove the solvent in vacuo

出典と根拠

ORDレコード
ord-80e0c4ba2f7e491a9d970aac7c67dcad
出典データセット
uspto-grants-1989_07
特許番号
US04851526

反応ノート

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