Isopropylamine → Ethyl isopropylcarbamate

To a solution of ethyl chloroformate (21.7 g, 0.2 mol) in 200 ml ether cooled to 0° C. was added dropwise 35.7 ml of isopropylamine with stirring and cooling. After complete addition of the amine, the reaction mixture was stirred at room temperature for an additional 0.5 hour. The reaction mixture was filtered, and the ether solution was washed with water, and dried over magnesium sulfate. Evaporation of the ether and distillation of the residue in a Kugelrohr apparatus resulted in 22.6 g of the title compound B.p.: 50°-66° C. (bath temperature) at 1.5 mm Hg.

1. temperaturecooling
2. stirringthe reaction mixture was stirred at room temperature for an additional 0.5 hour
3. filtrationThe reaction mixture was filtered
4. washthe ether solution was washed with water
5. dry with materialdried over magnesium sulfate
6. customEvaporation of the ether and distillation of the residue in a Kugelrohr apparatus

ORDレコード

ord-2587c72209fe41d9a175c739a551b879

出典データセット

uspto-grants-1997_01

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05591764