Thionyl Chloride → 4-[2-(4-Chloromethylphenoxy)ethyl]-5-methyl-2-phenyloxazole

HRID 233276ノート

反応式

HRID 233276 の反応式
[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:13][CH2:14][O:15][C:16]1[CH:23]=[CH:22][C:19]([CH2:20]O)=[CH:18][CH:17]=1.S(Cl)([Cl:26])=O>C(Cl)(Cl)Cl>[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:13][CH2:14][O:15][C:16]1[CH:23]=[CH:22][C:19]([CH2:20][Cl:26])=[CH:18][CH:17]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 118338284-[2-(5-Methyl-2-phenyl-4-oxazolyl)ethoxy]benzyl alcohol

生成物 1

HCID 118095944-[2-(4-Chloromethylphenoxy)ethyl]-5-methyl-2-phenyloxazole収率 90.2%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

To a solution of 4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzyl alcohol (6.8 g) in chloroform (100 ml) was added thionyl chloride (3.1 g), and the mixture was stirred for one hour at room temperature. The reaction mixture was washed with a saturated aqueous solution of sodium hydrogencarbonate and then water, followed by drying (MgSO4). The solvent was distilled off to leave 4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzyl chloride (6.5 g, 90%) as colorless needles, m.p.93°-94° C.

後処理

  1. washThe reaction mixture was washed with a saturated aqueous solution of sodium hydrogencarbonate
  2. dry with materialby drying (MgSO4)
  3. distillationThe solvent was distilled off

出典と根拠

ORDレコード
ord-01f8fcbfc83d407e8a9dcfa60ac58dcc
出典データセット
uspto-grants-1997_01
特許番号
US05591862

反応ノート

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