反応式
[CH:1]1[C:2]2[N:3]([CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:5][N:6]=1.[Li+].[CH3:11][CH:12]([N-]C(C)C)C.ICC.O>O1CCCC1>[CH2:11]([C:4]1[N:3]2[CH:7]=[CH:8][CH:9]=[C:2]2[CH:1]=[N:6][CH:5]=1)[CH3:12]参加物
6
反応条件
- 温度
- -78 °C
実験手順
1.0 g of pyrrolo[1,2-a]pyrazine prepared in Preparation Example 1 was dissolved in 10 ml of tetrahydrofuran and then cooled to -78° C. under nitrogen atmosphere. To this solution was added 1.2 equivalents of LDA solution; the resulting mixture was stirred for 30 minutes; and 1 ml of iodoethane was added to the mixture while maintaining the temperature of -78° C. The reaction mixture was stirred for 30 minutes, warmed to room temperature and then poured into water. The organic layer was isolated and then concentrated to dryness to obtain 0.3 g of title compound.
後処理
- temperaturewhile maintaining the temperature of -78° C
- stirringThe reaction mixture was stirred for 30 minutes
- temperaturewarmed to room temperature
- customThe organic layer was isolated
- concentrationconcentrated to dryness
出典と根拠
- ORDレコード
- ord-eb306ae1bfc344cba9a9536013cb01a2
- 出典データセット
- uspto-grants-1997_01
- 特許番号
- US05593984
関連ノート
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