Hydrochloric Acid → 4-Bromo-2,3-dihydro-1H-inden-1-ol

HRID 234078

反応式

HRID 234078 の反応式
[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][CH2:5][C:6]2=[O:11].[BH4-].[Na+].Cl>C(O)C.O1CCCC1>[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][CH2:5][CH:6]2[OH:11]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 987131-Indanone, 4-bromo-HCID 4311764Sodium borohydride

生成物 1

HCID 133302084-Bromo-2,3-dihydro-1H-inden-1-ol

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 4-bromo-1-indanone (1.0 g) in a mixture of ethanol (6 ml) and tetrahydrofuran (3 ml) was added sodium borohydride (0.09 g) at an ice temperature. The reaction mixture was stirred at the same temperature overnight and poured into dilute hydrochloric acid, and the aqueous layer was saturated with saline and extracted with ether. The organic layer was washed with a saturated aqueous saline, dried over sodium sulfate, and the solvent was removed by distillation under reduced pressure. The residual concentrate (1.02 g) thus obtained was used for the next reaction without further purification.

後処理

  1. extractionextracted with ether
  2. washThe organic layer was washed with a saturated aqueous saline
  3. dry with materialdried over sodium sulfate
  4. customthe solvent was removed by distillation under reduced pressure
  5. concentrationThe residual concentrate (1.02 g)
  6. customthus obtained
  7. customwas used for the next reaction without further purification

出典と根拠

ORDレコード
ord-01f71f65fdf84ea39e9ca101f8c5f389
出典データセット
uspto-grants-1997_01
特許番号
US05594081

関連ノート

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