Bromine → 5-Isopropyl-2-nitro-4-thiocyanato-phenylamine

HRID 23484

反応式

HRID 23484 の反応式
[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([N+:11]([O-:13])=[O:12])=[C:8]([NH2:10])[CH:9]=1)([CH3:3])[CH3:2].[S-:14][C:15]#[N:16].[Na+].[Br-].[Na+].BrBr>CO>[CH:1]([C:4]1[C:5]([S:14][C:15]#[N:16])=[CH:6][C:7]([N+:11]([O-:13])=[O:12])=[C:8]([NH2:10])[CH:9]=1)([CH3:3])[CH3:2]

参加物

6

反応物 4

HCID 24408BromineHCID 253881Sodium BromideHCID 516871Sodium thiocyanateHCID 225728525-Isopropyl-2-nitroaniline

生成物 1

HCID 225729135-Isopropyl-2-nitro-4-thiocyanato-phenylamine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

The title compound was prepared according to General Method 13 using 5-isopropyl-2-nitro-phenylamine (prepared in Example PP-1; 5.4 g, 30 mmol), sodium thiocyanate (14.6 g, 180 mmol), sodium bromide (3.7 g, 35.99 mmol), bromine (5.75 g, 36.0 mmol), and MeOH (100 mL). The crude reaction mixture was purified by flash silica gel chromatography (5%-50% EtOAc in hexanes as eluents). MS(APCI): 238 (M+H).

後処理

  1. customThe crude reaction mixture
  2. customwas purified by flash silica gel chromatography (5%-50% EtOAc in hexanes as eluents)

出典と根拠

ORDレコード
ord-233cc62428524c4396e8779a88af5ae1
出典データセット
uspto-grants-2005_02
特許番号
US06852711B2

関連ノート

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