Diethyl Sulfate → HCID 19856557、化合物

HRID 2351039ノート

反応式

HRID 2351039 の反応式
[Br:1][C:2]1[C:3](=[O:9])[NH:4][CH:5]=[C:6]([Br:8])[N:7]=1.[OH-].[Na+].C(=O)([O-])[O-].[Na+].[Na+].S(OCC)(O[CH2:22][CH3:23])(=O)=O>O>[CH2:22]([N:4]1[CH:5]=[C:6]([Br:8])[N:7]=[C:2]([Br:1])[C:3]1=[O:9])[CH3:23]

参加物

6

反応物 4

HCID 6163Diethyl SulfateHCID 10340Sodium CarbonateHCID 14798Sodium HydroxideHCID 167408633,5-Dibromopyrazin-2(1H)-one

生成物 1

HCID 19856557HCID 19856557、化合物収率 66.8%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

6.2 g of 3,5-dibromo-pyrazin-2-one are suspended in a mixture of 38 ml of water, 11.1 ml of 2 N sodium hydroxide solution and 0.5 g of sodium carbonate. 4.3 g of diethyl sulfate are then added dropwise at 20°-25° C. and the mixture is subsequently stirred at the same temperature for 15 hours. The product is filtered off at 0° C., washed with ice-water and dried to give 4.6 g of 1-ethyl-3,5-dibromo-pyrazin-2-one.

後処理

  1. filtrationThe product is filtered off at 0° C.
  2. washwashed with ice-water
  3. customdried

出典と根拠

ORDレコード
ord-e738456320634a1da128b631dc0f6271
出典データセット
uspto-grants-1989_10
特許番号
US04871853

反応ノート

読み込み中…