Ammonia → 2-Undecyl-2-oxazoline

HRID 2352192

反応式

HRID 2352192 の反応式
[CH2:1]([C:12]#[N:13])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11].N[CH2:15][CH2:16][OH:17].N>O.O.C([O-])(=O)C.[Cd+2].C([O-])(=O)C.C(O)CCC>[CH2:1]([C:12]1[O:17][CH2:16][CH2:15][N:13]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11]

参加物

6

反応物 3

HCID 222AmmoniaHCID 700EthanolamineHCID 17092Dodecanenitrile

生成物 1

HCID 3470762-Undecyl-2-oxazoline収率 88%

試薬・触媒・溶媒 2

HCID 6537495Cadmium acetate, dihydrate触媒HCID 2631-Butanol溶媒

反応条件

温度
125 °C

実験手順

The reaction was carried out under nitrogen atmosphere in a three neck flask equipped with a magnetic stirring bar, reflux condenser, addition funnel and thermometer. 50 ml of 1-butanol and 667 mg (2.5 mmoles) of cadmium acetate dihydrate was introduced and the catalyst was dissolved by slight warming. 18.13 g (100 mmoles) of undecyl cyanide was added and the solution was heated to 125° C. 7.33 g (120 mmoles) of 2-aminoethanol was then added dropwise controlling the evolution of ammonia. At the end of the reaction (ca. 48 hrs.) the solvent was removed under vacuo. The residue was treated with 100 ml of petroleum ether and filtered after keeping for several hours. The filtrate was washed with water, dried over anhydrous magnesium sulfate, concentrated and the residue was distilled 114° C./0.5mm to give 19.83 g (88%) of 2-undecyl-2oxazoline.

後処理

  1. customequipped with a magnetic stirring bar
  2. temperaturereflux
  3. additioncondenser, addition funnel
  4. dissolutionthe catalyst was dissolved by slight warming
  5. customAt the end of the reaction (ca. 48 hrs.) the solvent
  6. customwas removed under vacuo
  7. additionThe residue was treated with 100 ml of petroleum ether
  8. filtrationfiltered
  9. waitafter keeping for several hours
  10. washThe filtrate was washed with water
  11. dry with materialdried over anhydrous magnesium sulfate
  12. concentrationconcentrated
  13. distillationthe residue was distilled 114° C./0.5mm

出典と根拠

ORDレコード
ord-c9cabac028614f0abd006ec5a1e28210
出典データセット
uspto-grants-1989_10
特許番号
US04876249

関連ノート

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