Water → 4-Methyl-2-undecyl-2-oxazoline-4-methanol

HRID 2352199ノート

反応式

HRID 2352199 の反応式
[C:1]([OH:14])(=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].[NH2:15][C:16]([CH3:21])([CH2:19]O)[CH2:17][OH:18].O>C1(C)C(C)=CC=CC=1.C(OCC)(=O)C>[OH:18][CH2:17][C:16]1([CH3:21])[CH2:19][O:14][C:1]([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])=[N:15]1

参加物

6

反応物 3

HCID 962WaterHCID 15312-Amino-2-methyl-1,3-propanediolHCID 3893Lauric Acid

生成物 1

HCID 735074-Methyl-2-undecyl-2-oxazoline-4-methanol収率 84.6%

試薬・触媒・溶媒 2

HCID 7237O-Xylene溶媒HCID 8857Ethyl Acetate溶媒

実験手順

A mixture of 20.03 g (100 mmoles) of dodecanoic acid and 11.57 g (110) mmoles) of 2-amino-2-methyl-1,3propanediol in 10 ml of xylene was heated for 30 hours at 185°-190°C. with azeotropic removal of water. The reaction mixture was taken up in ethyl acetate and was washed with water to remove excess amino alcohol. The organic layer was dried, concentrated and the residue was distilled at 152°-155° C./ 1 mmHg to give 22.8 g (84.6%) of 4-hydroxymethyl-4-methyl-2-undecyl-2oxazoline.

後処理

  1. washwas washed with water
  2. customto remove excess amino alcohol
  3. customThe organic layer was dried
  4. concentrationconcentrated
  5. distillationthe residue was distilled at 152°-155° C./ 1 mmHg

出典と根拠

ORDレコード
ord-60fe064ac7264cf1aefd49c9da80aac9
出典データセット
uspto-grants-1989_10
特許番号
US04876249

反応ノート

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