Morpholine → 4-(4-Nitropyridin-2-yl)morpholine

HRID 2353548

反応式

HRID 2353548 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][N:7]=[CH:6][CH:5]=1)([O-:3])=[O:2].[NH:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1>C1COCC1>[N+:1]([C:4]1[CH:9]=[CH:8][N:7]=[C:6]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[CH:5]=1)([O-:3])=[O:2]

参加物

4

反応物 2

HCID 8083MorpholineHCID 707344-Nitropyridine

生成物 1

HCID 574185464-(4-Nitropyridin-2-yl)morpholine収率 56.5%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 2-chloro, 4-nitropyridine (0.2 g, 1.27 mmol) in THF (3 mL) was added morpholine (328 mg, 38.1 mmol). The reaction was heated to 80C and stirred overnight. The solvent was evaporated and the residue purified by column chromatography (2/1 Hex/EtOAc) to yield 150 mg of the target compound.

後処理

  1. customThe solvent was evaporated
  2. customthe residue purified by column chromatography (2/1 Hex/EtOAc)

出典と根拠

ORDレコード
ord-2980c9148a43422cb224823d9fcf9fe8
出典データセット
uspto-grants-2010_07
特許番号
US07749999B2

関連ノート

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