Hydrochloric Acid → n-[5-(4,4-Dimethyl-2,5-dioxo-3-pyridin-4-ylmethyl-imidazolidin-1-yl)-2-isopropyl-phenyl]-2-chloro-acetamide

HRID 2356942ノート

反応式

HRID 2356942 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]([N:11]2[C:15](=[O:16])[C:14]([CH3:18])([CH3:17])[N:13]([CH2:19][C:20]3[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=3)[C:12]2=[O:26])[CH:5]=[CH:6][C:7]=1[CH:8]([CH3:10])[CH3:9].CCN(C(C)C)C(C)C.[Cl:36][CH2:37][C:38](Cl)=[O:39].Cl>ClCCCl>[CH3:18][C:14]1([CH3:17])[C:15](=[O:16])[N:11]([C:4]2[CH:5]=[CH:6][C:7]([CH:8]([CH3:9])[CH3:10])=[C:2]([NH:1][C:38](=[O:39])[CH2:37][Cl:36])[CH:3]=2)[C:12](=[O:26])[N:13]1[CH2:19][C:20]1[CH:21]=[CH:22][N:23]=[CH:24][CH:25]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 6577Chloroacetyl chlorideHCID 81531DiisopropylethylamineHCID 115304483-(3-Amino-4-isopropyl-phenyl)-5,5-dimethyl-1-pyridin-4-ylmethyl-imidazolidine-2,4-dione

生成物 1

HCID 23110307n-[5-(4,4-Dimethyl-2,5-dioxo-3-pyridin-4-ylmethyl-imidazolidin-1-yl)-2-isopropyl-phenyl]-2-chloro-acetamide

試薬・触媒・溶媒 1

HCID 111,2-Dichloroethane溶媒2 回

反応条件

温度
-20 °C

実験手順

1.37 mg (3.89 mmol) 3-(3-amino-4-isopropyl-phenyl)-5,5-dimethyl-1-pyridin-4-ylmethyl-imidazolidine-2,4-dione and 528 mg (4.08 mmol) Hünig's base were dissolved in 50 ml 1,2-dichloroethane. The mixture was cooled to −20° C. and treated with a solution of 439 mg (3.89 mmol) chloroacetylchlorid in 20 ml 1,2-dichloroethane. After stirring 1 h at 0° C., 25 ml ethanolic hydrochloric acid were added and the mixture evaporated to dryness. The raw material, containing huening's base hydrochloride was used without further purification.

後処理

  1. customthe mixture evaporated to dryness
  2. additionThe raw material, containing huening's base hydrochloride
  3. customwas used without further purification

出典と根拠

ORDレコード
ord-1a9e51d6e0f94d7f973c7cf5930e1bdb
出典データセット
uspto-grants-2010_07
特許番号
US07759379B2

反応ノート

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