Potassium Carbonate → HCID 68455771、化合物

反応式

[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](Cl)=[N:7][N:6]=[CH:5]2.[CH3:13][N:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8]([N:17]1[CH2:18][CH2:19][N:14]([CH3:13])[CH2:15][CH2:16]1)=[N:7][N:6]=[CH:5]2

参加物

反応条件

温度: 180 °C

実験手順

A mixture of 6-bromo-1-chlorophthalazine (0.12 g, 0.5 mmol), 1-methylpiperazine (0.11 mL, 1.0 mmol) and potassium carbonate (0.07 g, 0.5 mmol) in ACN (5 mL) was added to a glass microwave reaction vessel. The reaction mixture was stirred and heated in a Smith Synthesizer® microwave reactor (Personal Chemistry, Inc., Upssala, Sweden) at 180° C. for 20 min. The mixture was concentrated in vacuo, and was purified by flash chromatography (silica gel) eluting with 2% 2 M ammonia in methanol/dichloromethane to 6% 2 M ammonia in MeOH/D)CM to give 6-bromo-1-(4-methylpiperazin-1-yl)phthalazine as yellow solid. MS (ES+): 307, 309 (M+H)+.