Sodium Hydroxide → 3-(1-Isopropylphthalazin-6-yl)-4-methylbenzoic acid

HRID 2357543ノート

反応式

HRID 2357543 の反応式
[CH:1]([C:4]1[C:13]2[C:8](=[CH:9][C:10]([C:14]3[CH:15]=[C:16]([CH:22]=[CH:23][C:24]=3[CH3:25])[C:17]([O:19]CC)=[O:18])=[CH:11][CH:12]=2)[CH:7]=[N:6][N:5]=1)([CH3:3])[CH3:2].[OH-].[Na+]>O1CCCC1.CO>[CH:1]([C:4]1[C:13]2[C:8](=[CH:9][C:10]([C:14]3[CH:15]=[C:16]([CH:22]=[CH:23][C:24]=3[CH3:25])[C:17]([OH:19])=[O:18])=[CH:11][CH:12]=2)[CH:7]=[N:6][N:5]=1)([CH3:3])[CH3:2]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 68455777Ethyl 3-(1-isopropylphthalazin-6-yl)-4-methylbenzoate

生成物 1

HCID 684522933-(1-Isopropylphthalazin-6-yl)-4-methylbenzoic acid

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of ethyl 3-(1-isopropylphthalazin-6-yl)-4-methylbenzoate (37.5 mg, 0.11 mmol) in tetrahydrofuran (0.3 mL) and methanol (0.15 mL) was treated with 1N aq. sodium hydroxide (0.28 mL, 0.28 mmol) and stirred at RT for 18 h. The reaction mixture was concentrated in vacuo and the residue was taken up in water. The pH was adjusted with 10% HCl solution to ˜7. The precipitate formed was collected via filtration and dried under high vacuum to afford the title compound as a maize-colored solid. MS (ES+): 307.2 (M+H)+.

後処理

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customThe precipitate formed
  3. filtrationwas collected via filtration
  4. customdried under high vacuum

出典と根拠

ORDレコード
ord-a7e68c960a7c40c980802abcf80c3f6b
出典データセット
uspto-grants-2010_07
特許番号
US07759337B2

反応ノート

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