HCID 68455295、化合物 → HCID 51357134、化合物
反応式
[CH2:1]([N:8]([C@H:13]([CH3:16])[CH2:14][OH:15])[C:9](=[O:12])[CH2:10]Cl)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C1COCC1.[H-].[Na+]>[CH2:1]([N:8]1[C@H:13]([CH3:16])[CH2:14][O:15][CH2:10][C:9]1=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
4
実験手順
(R)-N-Benzyl-2-chloro-N-(1-hydroxypropan-2-yl)acetamide (9.49 g, 39.3 mmol) was dissolved in THF (78.5 mL) before NaH—60% in oil (1.73 g, 43.2 mmol) was added and the mixture stirred at reflux for 4 h. The reaction was quenched with a few drops of water, concentrated, diluted with dichloromethane, filtered, and concentrated to give the title compound. MS (ES+): 206(M+H)+.
後処理
- additionwas added
- temperatureat reflux for 4 h
- customThe reaction was quenched with a few drops of water
- concentrationconcentrated
- additiondiluted with dichloromethane
- filtrationfiltered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-70ad3f4d271f4c8cae38d92229cc81be
- 出典データセット
- uspto-grants-2010_07
- 特許番号
- US07759337B2
反応ノート
読み込み中…