Diethyl Carbonate → HCID 68637486、化合物

HRID 2357871ノート

反応式

HRID 2357871 の反応式
[F:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([F:9])=[CH:4][C:3]=1[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12].[CH2:16]([O:18][C:19](=O)[O:20]CC)[CH3:17].[H-].[Na+]>C1(C)C=CC=CC=1>[CH2:14]([O:13][C:11](=[O:12])[CH:10]([C:3]1[CH:4]=[C:5]([F:9])[CH:6]=[C:7]([F:8])[C:2]=1[F:1])[C:19]([O:18][CH2:16][CH3:17])=[O:20])[CH3:15]

参加物

5

反応物 3

HCID 7766Diethyl CarbonateHCID 24758Sodium hydrideHCID 53419349Benzoic acid, 2,3,5-trifluoro-, ethyl ester

生成物 1

HCID 68637486HCID 68637486、化合物収率 82.9%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

Ethyl 2-(2,3,5-trifluorophenyl)-acetate (29 g) was slowly added to a mixture of diethylcarbonate (63 g) and sodium hydride (9.5 g) in toluene (350 ml). After being refluxed for 3 hours, the reaction mixture was cooled, treated with ice-water and washed with water. The organic layer was separated, dried and filtered. The filtrate was concentrated in vacuo to yield 32 g of the title compound.

後処理

  1. temperatureAfter being refluxed for 3 hours
  2. temperaturethe reaction mixture was cooled
  3. washwashed with water
  4. customThe organic layer was separated
  5. customdried
  6. filtrationfiltered
  7. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-b4adab8be14a42df801d63a3755c957b
出典データセット
uspto-grants-2010_07
特許番号
US07763622B2

反応ノート

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