Formaldehyde → 4-(2-Bromo-2,2-difluoro-ethyl)-1-hydroxymethyl-pyrrolidin-2-one

HRID 2358229ノート

反応式

HRID 2358229 の反応式
[Br:1][C:2]([F:11])([F:10])[CH2:3][CH:4]1[CH2:8][NH:7][C:6](=[O:9])[CH2:5]1.[CH2:12]=[O:13]>C[Si](Cl)(C)C>[Br:1][C:2]([F:10])([F:11])[CH2:3][CH:4]1[CH2:8][N:7]([CH2:12][OH:13])[C:6](=[O:9])[CH2:5]1

参加物

4

反応物 2

HCID 712FormaldehydeHCID 589112584-(2-Bromo-2,2-difluoro-ethyl)-pyrrolidin-2-one

生成物 1

HCID 113573434-(2-Bromo-2,2-difluoro-ethyl)-1-hydroxymethyl-pyrrolidin-2-one収率 93%

試薬・触媒・溶媒 1

HCID 6397Chlorotrimethylsilane溶媒

実験手順

In a 50 ml three necked flask fitted with a magnetic stirrer, under inert atmosphere, a solution of 4-(2-bromo-2,2-difluoro-ethyl)-pyrrolidin-2-one a6 (0.46 g, 2 mmol), paraformaldehyde (0.12 g) and TMSCl (10 ml) is heated at 60° C. for 1 h. The reaction mixture is evaporated to give the crude 4-(2-bromo-2,2-difluoro-ethyl)-1-hydroxymethyl-pyrrolidin-2-one a7 (0.48 g, 92%).

後処理

  1. customThe reaction mixture is evaporated

出典と根拠

ORDレコード
ord-5dd6a68815664df9be35bc92fc49b330
出典データセット
uspto-grants-2010_07
特許番号
US07763644B2

反応ノート

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