Hydrochloric Acid → 2-(3-Methoxyphenyl)cyclopropane-1-carboxylic acid

HRID 2358448

反応式

HRID 2358448 の反応式
C([O:3][C:4]([CH:6]1[CH2:8][CH:7]1[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([O:15][CH3:16])[CH:10]=1)=[O:5])C.Cl>CCO.[OH-].[Na+]>[CH3:16][O:15][C:11]1[CH:10]=[C:9]([CH:7]2[CH2:8][CH:6]2[C:4]([OH:5])=[O:3])[CH:14]=[CH:13][CH:12]=1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 19358490Cyclopropanecarboxylic acid, 2-(3-methoxyphenyl)-, ethyl ester

生成物 1

HCID 139722332-(3-Methoxyphenyl)cyclopropane-1-carboxylic acid

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

The crude 2-(3-methoxy-phenyl)-cyclopropanecarboxylic acid ethyl ester is dissolved in 30 ml EtOH and 15 ml 1N NaOH. After stirring over night, the reaction mixture is acidified with 1N HCl and extracted with diethyl ether. After removal of the solvent 7.1 g of the 2-(3-methoxy-phenyl)-cyclopropanecarboxylic acid is obtained. This 2-(3-methoxy-phenyl)-cyclopropanecarboxylic acid is used without further purification.

後処理

  1. extractionextracted with diethyl ether
  2. customAfter removal of the solvent 7.1 g of the 2-(3-methoxy-phenyl)-cyclopropanecarboxylic acid
  3. customis obtained
  4. customThis 2-(3-methoxy-phenyl)-cyclopropanecarboxylic acid is used without further purification

出典と根拠

ORDレコード
ord-115159adedc34e79819ccca64391392a
出典データセット
uspto-grants-2010_07
特許番号
US07763728B2

関連ノート

読み込み中…