Iodoethane → 2-Butyl-6-(2,5-dimethyl-pyrrol-1-yl)-pyridine

反応式

[CH3:1][C:2]1[N:3]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([CH3:14])[N:9]=2)[C:4]([CH3:7])=[CH:5][CH:6]=1.[CH2:15](I)[CH2:16][CH3:17].C(I)C>>[CH2:14]([C:10]1[CH:11]=[CH:12][CH:13]=[C:8]([N:3]2[C:2]([CH3:1])=[CH:6][CH:5]=[C:4]2[CH3:7])[N:9]=1)[CH2:15][CH2:16][CH3:17]

参加物

反応物 3

HCID 6340Iodoethane

HCID 336431-Iodopropane

HCID 7931562-(2,5-Dimethyl-1H-pyrrol-1-yl)-6-methylpyridine

生成物 1

HCID 133983052-Butyl-6-(2,5-dimethyl-pyrrol-1-yl)-pyridine収率 64.4%

実験手順

The product from Example 2a 1.0 g, 5.37 mmol) was reacted with propyl iodide 0.55 mL, 5.64 mmol) in place of ethyl iodide following the procedure from Example 2b to give the title compound (790 mg, 64%).

出典と根拠

ORDレコード: ord-89d09835880d42a8a45f27d8d01f4814
出典データセット: uspto-grants-2010_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07763731B2

反応ノート

読み込み中…