Ethyl bromoacetate → HCID 13773134、化合物

反応式

[CH3:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([NH:8][CH2:9][C:10]([C:12]2[O:13][CH:14]=[CH:15][CH:16]=2)=[O:11])=[O:7])=[CH:4][CH:3]=1.[H-].[Na+].Br[CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24]>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([NH:8][CH:9]([C:10]([C:12]2[O:13][CH:14]=[CH:15][CH:16]=2)=[O:11])[CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24])=[O:7])=[CH:17][CH:18]=1

参加物

反応物 3

HCID 7748Ethyl bromoacetate

HCID 24758Sodium hydride

HCID 13773124N-(2-(Furan-2-yl)-2-oxoethyl)-4-methylbenzamide

生成物 1

HCID 13773134HCID 13773134、化合物収率 85.6%

実験手順

12.0 g of N-(4-methylbenzoyl)-(2-furylcarbonyl)methylamine, 2.3 g of 61% sodium hydride and 9.1 g of ethyl bromoacetate are treated in the same manner as described in Preparation 1-(2). 13.9 g of ethyl 3-(4-methylbenzoylamino)-3-(2-furylcarbonyl)propionate are thereby obtained. Yield: 85.5%