Ethyl bromoacetate → HCID 13773137、化合物

反応式

[C:1]([NH:6][CH2:7][C:8]([C:10]1[O:11][CH:12]=[CH:13][CH:14]=1)=[O:9])(=[O:5])[CH:2]([CH3:4])[CH3:3].[H-].[Na+].Br[CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20]>>[C:1]([NH:6][CH:7]([C:8]([C:10]1[O:11][CH:12]=[CH:13][CH:14]=1)=[O:9])[CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])(=[O:5])[CH:2]([CH3:4])[CH3:3]

参加物

反応物 3

HCID 7748Ethyl bromoacetate

HCID 24758Sodium hydride

HCID 13773127N-[2-(Furan-2-yl)-2-oxoethyl]-2-methylpropanamide

生成物 1

HCID 13773137HCID 13773137、化合物収率 64.2%

実験手順

13.0 g of N-isobutyryl-(2-furylcarbonyl)methylamine, 3.1 g of 61% sodium hydride and 12.2 g of ethyl bromoacetate are treated in the same manner as described in Preparation 1-(2). 12.0 g of ethyl 3-isobutyrylamino-3-(2-furylcarbonyl)propionate are thereby obtained. Yield: 64.2%