Ethyl bromoacetate → HCID 13773138、化合物

反応式

[CH:1]1([C:7]([NH:9][CH2:10][C:11]([C:13]2[O:14][CH:15]=[CH:16][CH:17]=2)=[O:12])=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[H-].[Na+].Br[CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23]>>[CH:1]1([C:7]([NH:9][CH:10]([C:11]([C:13]2[O:14][CH:15]=[CH:16][CH:17]=2)=[O:12])[CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23])=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

反応物 3

HCID 7748Ethyl bromoacetate

HCID 24758Sodium hydride

HCID 13773128N-[2-(Furan-2-yl)-2-oxoethyl]cyclohexanecarboxamide

生成物 1

HCID 13773138HCID 13773138、化合物収率 56.3%

実験手順

6.5 g of N-cyclohexylcarbonyl-(2-furylcarbonyl)methylamine, 1.3 g of 61% sodium hydride and 5.1 g of ethyl bromoacetate are treated in the same manner as described in Preparation 1-(2). 5.0 g ethyl 3-cyclohexylcarbonylamino-3-(2-furylcarbonyl)propionate are thereby obtained. Yield: 56.2%