Methyl Anthranilate → 2-Aminobenzohydroxamic acid
反応式
[OH-:1].[Na+].[NH2:3]O.Cl.[C:6]([O:15]C)(=O)[C:7]1[C:8](=[CH:10][CH:11]=[CH:12][CH:13]=1)[NH2:9]>O>[OH:1][NH:3][C:6](=[O:15])[C:7]1[C:8](=[CH:10][CH:11]=[CH:12][CH:13]=1)[NH2:9]参加物
5
実験手順
48 parts of NaOH are introduced into 300 parts of water. 41.6 parts of NH2OH.HCl are added in portions, with cooling, followed by 45.2 parts of methyl anthranilate. After the mixture has been left to stand at room temperature for 3 days, the solution is concentrated and concentrated hydrochloric acid is added to the residue thus obtained until the pH is 6. After the mixture has been filtered and the filtrate has been washed with ethanol, anthranilic acid hydroxylamide is obtained as colourless crystals of melting point 140°-142° C. with a yield of 85%.
後処理
- temperaturewith cooling
- waitAfter the mixture has been left
- concentrationthe solution is concentrated
- additionconcentrated hydrochloric acid is added to the residue
- customthus obtained until the pH is 6
- filtrationAfter the mixture has been filtered
- washthe filtrate has been washed with ethanol
出典と根拠
- ORDレコード
- ord-e53a201a113545f09153d46d703ed5a9
- 出典データセット
- uspto-grants-1987_02
- 特許番号
- US04642322
反応ノート
読み込み中…