反応式
[NH2:1][C:2]1[N:3]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)[C:4]2[N:5]([CH2:11][CH:12]([CH3:14])[N:13]=2)[C:6](=[O:10])[C:7]=1[N:8]=O.S(S([O-])(=O)=O)([O-])(=O)=O.[Na+].[Na+].N1C=CC=[CH:35][CH:34]=1.C(OC(=O)C)(=O)C>C(O)=O.C(#N)C>[Cl:22][C:19]1[CH:20]=[CH:21][C:16]([CH2:15][N:3]2[C:2]3[NH:1][C:34]([CH3:35])=[N:8][C:7]=3[C:6](=[O:10])[N:5]3[CH2:11][CH:12]([CH3:14])[N:13]=[C:4]23)=[CH:17][CH:18]=1参加物
7
反応物 4
生成物 1
試薬・触媒・溶媒 2
実験手順
The product of Procedure 99 was reduced with sodium dithionate in formic acid according to the method of Procedure 21. The resulting 7-amino-4-[(4-chlorophenyl)-methyl]-2,3-dihydro-6-formylamino-2-methylimidazo[1,2-a]pyrimidin-5-(8H)-one, 3.5 g. (0.0104 mole) in 7 ml. of pyridine and 7 ml. of acetic anhydride was refluxed for three 3 hrs. during which the mixture foamed and turned dark. The mixture was allowed to cool to room temperature and diluted with acetonitrile resulting in the formation of a white precipitate which was collected. Recrystallized from iPROH/MeOH, yield 800 mg., m.p. 290°-291° C.
後処理
- customwas collected
- customRecrystallized from iPROH/MeOH, yield 800 mg
出典と根拠
- ORDレコード
- ord-3e469c7f6c42491d96434cf4e01bc708
- 出典データセット
- uspto-grants-1987_02
- 特許番号
- US04642345
関連ノート
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