Isoamyl Nitrite → 5-Tert-butyl-2-methoxy-1-methylsulphanyl-3-nitro-benzene
反応式
[C:1]([C:5]1[CH:6]=[C:7]([N+:14]([O-:16])=[O:15])[C:8]([O:12][CH3:13])=[C:9](N)[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].C(ON=O)CC(C)C.[CH3:25][S:26]SC>C(#N)C>[C:1]([C:5]1[CH:6]=[C:7]([N+:14]([O-:16])=[O:15])[C:8]([O:12][CH3:13])=[C:9]([S:26][CH3:25])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2]参加物
5
実験手順
2 g 5-tert-butyl-2-methoxy-3-nitro-phenylamine are dissolved in 20 ml acetonitrile, combined successively with 3.6 ml isopentylnitrite as well as 2.4 ml dimethyldisulphide and refluxed for 2 h. The solvents are eliminated in vacuo and the residue is chromatographed on silica gel (petroleum ether/ethyl acetate 90:10).
後処理
- temperaturerefluxed for 2 h
- customthe residue is chromatographed on silica gel (petroleum ether/ethyl acetate 90:10)
出典と根拠
- ORDレコード
- ord-26183b1c99964a2bbba39c3fccd96cb7
- 出典データセット
- uspto-grants-2014_04
- 特許番号
- US08686022B2
反応ノート
読み込み中…