Sodium Hydroxide → HCID 178516346、化合物
反応式
[OH-:1].[Na+].ClC(Cl)(Cl)[C:5]1[CH:10]=[CH:9][N:8]2[C:11]3[CH:17]=[CH:16][CH:15]=[CH:14][C:12]=3[N:13]=[C:7]2[N:6]=1>C(#N)C>[N:6]1[C:7]2[N:8]([C:11]3[CH:17]=[CH:16][CH:15]=[CH:14][C:12]=3[N:13]=2)[CH:9]=[CH:10][C:5]=1[OH:1]参加物
4
実験手順
Sodium hydroxide (36.5 ml, 36.5 mmol) was added to a solution containing 2-(trichloromethyl)-benzo[4,5]imidazo[1,2-a]pyrimidine (8.04 g, 28.1 mmol) in Acetonitrile (Volume: 122 ml). Heated the reaction to 90 C for 30 minutes. Cooled the reaction to room temperature and concentrated. Added ice to the resulting residue, followed by 35 mL of 1M HCl. Filtered the solid and dried under vacuum to afford crude benzo[4,5]imidazo[1,2-a]pyrimidin-2-ol (5.2 g, 28.1 mmol, 100% yield).
後処理
- temperatureHeated
- customthe reaction to 90 C for 30 minutes
- temperatureCooled
- customthe reaction to room temperature
- concentrationconcentrated
- filtrationFiltered the solid
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-20435265506d481984f80f3594002810
- 出典データセット
- uspto-grants-2014_04
- 特許番号
- US08691187B2
反応ノート
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