Trimethylamine → 2,3-Epoxypropyltrimethylammonium bromide
反応式
[CH3:1][N:2]([CH3:4])[CH3:3].[CH2:5]([CH:7]1[O:9][CH2:8]1)[Br:6]>CC(C)=O>[Br-:6].[O:9]1[CH2:8][CH:7]1[CH2:5][N+:2]([CH3:4])([CH3:3])[CH3:1]参加物
4
反応条件
- 温度
- 10 °C
実験手順
A flask equipped with a sparger, mechanical stirrer, thermometer and efficiency condenser was charged with acetone (500 milliliters) at ambient temperature. Trimethylamine (58 grams, 0.98 mol) was charged into the solution. The pot was cooled to 10° C. and epibromohydrin (137 grams, 1.0 mol) was added dropwise over a 1 hour period. The resultant cloudy solution was allowed to slowly rise to ambient temperature and stand for 60 hours. Precipitate was collected by filtration washed with acetone (60 milliliters) and dried yielding a colorless crystalline product (179.4 grams, 94%).
後処理
- customA flask equipped with a sparger, mechanical stirrer, thermometer and efficiency condenser
- customto slowly rise to ambient temperature
- filtrationPrecipitate was collected by filtration
- washwashed with acetone (60 milliliters)
- customdried
出典と根拠
- ORDレコード
- ord-b855363253404447b1c1db1f70ea42fa
- 出典データセット
- uspto-grants-1987_02
- 特許番号
- US04645794
反応ノート
読み込み中…